Editorial: Natural Product Epigenetic Modulators and Inhibitors
نویسندگان
چکیده
منابع مشابه
Natural Product and Natural Product-Derived Gamma Secretase Modulators from Actaea Racemosa Extracts
Alzheimer's disease is characterized by pathogenic oligomerization, aggregation, and deposition of amyloid beta peptide (Aβ), resulting in severe neuronal toxicity and associated cognitive dysfunction. In particular, increases in the absolute or relative level of the major long form of Aβ, Aβ42, are associated with increased cellular toxicity and rapidity of disease progression. As a result of ...
متن کاملAnticancer Natural Compounds as Epigenetic Modulators of Gene Expression
Accumulating evidence shows that hallmarks of cancer include: "genetic and epigenetic alterations leading to inactivation of cancer suppressors, overexpression of oncogenes, deregulation of intracellular signaling cascades, alterations of cancer cell metabolism, failure to undergo cancer cell death, induction of epithelial to mesenchymal transition, invasiveness, metastasis, deregulation of imm...
متن کاملNatural product family 18 chitinase inhibitors.
Ole Andreas Andersen received hisM.Sc and Ph.D from theUniversity of Tromsø, Norway, in 1998 and 2003, respectively. His Ph.Dwork was supervised by Prof. Edward Hough and comprised crystallographic and biochemical studies on human phenylalanine hydroxylase. Andersen had a postdoctoral fellowship for one year at The Norwegian Structural Biology Centre in Tromsø under the supervision of Prof. Arn...
متن کاملNatural product-inspired cascade synthesis yields modulators of centrosome integrity.
In biology-oriented synthesis, the scaffolds of biologically relevant compound classes inspire the synthesis of focused compound collections enriched in bioactivity. This criterion is, in particular, met by the scaffolds of natural products selected in evolution. The synthesis of natural product-inspired compound collections calls for efficient reaction sequences that preferably combine multipl...
متن کاملNatural peptides and proteins: potent tyrosinase inhibitors
Background and objectives: Tyrosinase is a copper containing oxidase which is crucial for controlling the production of melanin in creatures such as bacteria, fungi, plants and mammals. It is involved in the first two steps of melanin biosynthesis and leads to pigmentation and different types of cancer such as melanoma. Also, it is responsible for browning of fruits and vegetab...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Frontiers in Pharmacology
سال: 2021
ISSN: 1663-9812
DOI: 10.3389/fphar.2021.651395